Common Variations in Perilipin rs1052700 and FTO rs3751812 Genes, Central Obesity, and Risk Type-2 Diabetes

Background: Perilipins are proteins at the external level of the lipid glob in adipocytes steroid-generating cells and play a central role in lipid storage and breakdown. FTO gene is associated with Type-2 diabetes (T2D) and increased fat mass. Association of Perilipin and FTO genes polymorphism with T2D was investigated. Methods: Clinical traits in a random sample of 183 Iranian men and women with T2D and 174 controls without any metabolic disease took part in the study. The sample was genotyped using Tetra-ARMS method. Results: In Perilipin (rs1052700) polymorphism tested, a significant association was found between this polymorphism and T2D (P=0.03). In FTO (rs3751812) polymorphism, a significant association was seen between this gene and obesity (P=0.003). But, no significant relation was found between this genotype and T2D. Conclusion: The rs3751812   polymorphism of FTO gene is the major genetic determinant of obesity, but not type-2 diabetes. The rs1052700 polymorphism of Perilipin gene is related to T2D but not obesity.